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STATE OF IOWA
KIM REYNOLDS
GOVERNOR
June 11, 2025
The Honorable Paul Pate
Secretary of State of Iowa
State Capitol Building
LOCAL
Dear Mr. Secretary:
I hereby transmit House File 383, an act relating to the controlled substance crystalline
polymorph psilocybin.
House File 383 would allow for Iowa doctors to prescribe a synthetic version of
psilocybin, a psychedelic compound found in mushrooms, should the United States Food
and Drug Administration ( FDA) approve the drug at some future date.
Psilocybin has been classified by the Drug Enforcement Agency ( DEA) as a Schedule I
controlled substance since 1970, which means that the scientific evidence has shown that
there is a high potential for abuse, it has an increased likelihood of causing severe
psychological and physical dependence, and there is a lack of acceptable medical uses.
I recognize and respect the growing body of research into the potential therapeutic
benefits of psilocybin for mental health conditions such as depression and PTSD.
However, this bill, in its current form, moves ahead of where our public health systems,
regulatory frameworks, and law enforcement infrastructure are prepared to go at this
time.
Moreover, House File 3 83 surrenders state authority to make an informed determination
about classification to federal officials at the FDA. Psilocybin should first be FDA
approved and rescheduled by the DEA before the State of Iowa considers rescheduling.
The pathway provided by this bill for legalization of psilocybin at the state level before
we have a chance to review federal action and prepare robust, federally aligned
guidelines and safeguards creates legal uncertainty, poses risks for misuse, and could
undermine broader efforts to ensure safe and effective therapeutic use in the future.
STATE CAPITOL DES MOINES, IOWA 50319 515.281.5211 WWW.GOVERNOR.IOWA.GOV
This decision is not a dismissal of the emerging science or the sincere advocacy behind
this legislation. Rather, it is a call for a more deliberate and Iowa- centric approach— one
that engages state and federal partners, provides time to review any clinical studies and
federal changes, and builds a framework for any future therapeutic access that is clear,
safe, equitable, and medically sound.
For these reasons, I respectfully disapprove of House File 383 in its entirety.
Sincerely,
op
Kim Reynolds
Governor of Iowa
cc: Secretary of the Senate
Clerk of the House
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House File 383
AN ACT
RELATING TO THE CONTROLLED SUBSTANCE CRYSTALLINE POLYMORPH
PSILOCYBIN.
BE IT ENACTED BY THE GENERAL ASSEMBLY OF THE STATE OF IOWA:
Section 1. Section 124.201, Code 2025, is amended by adding
the following new subsection:
NEW SUBSECTION. 5. a. Notwithstanding section 124.204,
subsection 4, a drug that contains the pharmaceutical
composition of crystalline polymorph psilocybin, also known as
COMP 360, or any other trade name approved by the United States
food and drug administration, shall be immediately removed
from schedule I under section 124.204, subsection 4, paragraph
" s" upon its approval by the United States food and drug
administration and rescheduled based upon the recommendations
of the United States food and drug administration and its
listing in the federal Controlled Substances Act, 21 U.S.C.
§ 812, and 21 C.F.R. § 1308.14.
b. Immediately upon the rescheduling of the drug under
paragraph " a - , it shall be lawful to prescribe, distribute, and
market the pharmaceutical composition of crystalline polymorph
House File 383, p. 2
psilocybin, also known as COMP 360, or any other trade name
approved by the United States food and drug administration.
PAT GRASSLEY
Speaker of the House President of the Senate
I hereby certify that this bill originated in the House and
is known as House File 383, Ninety-first General Assembly.
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App r- o*Qd 01 2025
MEGRAN NELSON
CM et Clerk of the House
KIM REYNOLDS
Governor
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